We are interested in developing versatile, wide-field functional imaging (WiFI) instrumentation that will simultaneously measure tissue blood flow, biochemical composition (i.e. oxy- and deoxy- hemoglobin, water and lipid content), and molecular fluorescence in biological tissues. Our goal is to attain sufficient spatio-temporal resolution to study both fast (i.e., ms timescale) and localized (i.e., tens of microns to mm) events at depths of several millimeters in thick tissues. We expect that WiFI instruments will enable chronic, noninvasive molecular sensing of biomarkers (gene expression, protein function, enzymatic reactions, blood flow, tissue oxygenation, etc.) directly related to the health status of the microvasculature. Please visit the BLI WiFI resource page for more information on WiFI.
Collaborators: Tony Durkin and Bruce Tromberg, UC Irvine; David Cuccia, Modulated Imaging Inc.; David Boas, Harvard Medical School; Brian Sorg, Univ. of Florida