Welcome to the webpage of the Microvascular Therapeutics & Imaging Laboratory at the Beckman Laser InstituteUniversity of California, Irvine!


  • The MTI lab is dedicated to development of new technologies and methodologies that enable scientists and clinicians to study the microvasculature, which comprises the small blood vessels found throughout the body.
  • We foster a cooperative environment in which postdoctoral scholars, graduate students, undergraduate students, and research staff collaborate with each other and with other scientists and clinicians to develop creative solutions tailored towards specific biological and clinical needs.
  • We place a major emphasis on training the next generation of biomedical engineers and clinicians.
  • Together, we envision making new discoveries that are expected to aid in our understanding of the role of the microvasculature in 1) normal physiological processes, 2) early-stage progression of many diseases, and 3) development of new treatment strategies.

Papers accepted for publication in two journals

The MTI lab recently participated in projects that resulted in three papers accepted for publication:

1) Dr. Adrien Ponticorvo, a Postdoctoral Scholar in Dr. Tony Durkin’s lab, is first author on “Quantitative assessment of graded burn wounds in a porcine model using spatial frequency domain imaging (SFDI) and laser speckle imaging (LSI)”, a paper that was accepted on 8 Sep 2014 for publication in Biomedical Optics Express.  The work was in collaboration with MTI lab members Drs. Bruce Yang and Bernard Choi, and the United States Army Institute of Surgical Research at Fort Sam Houston, San Antonio, TX (Drs. David Burmeister and Bob Christy).  Congratulations all!  [pdf]

2) Dr. Julio Ramirez-San-Juan, a Scientist at Instituto Nacional de Astrofísica, Óptica y Electrónica (INAOE) in Puebla, Mexico, is first author on “Spatial versus temporal laser speckle contrast analysis in the presence of static optical scatterers”, a paper that was accepted on 22 Sep 2014 for publication in Journal of Biomedical Optics.  The paper describes the remarkable ability of Laser Speckle Imaging, with temporal contrast analysis, to report measurements of flow that are largely independent of depth.  The work was in collaboration with MTI lab members Caitlin Regan and Dr. Choi.  Congratulations Julio and Caitlin!  [pdf]

3) Dr. Robert Wilson, a Hewitt Research Fellow working with Drs. Bruce Tromberg, Durkin, and Choi, is first author on “Quantitative short-wave infrared (SWIR) multispectral imaging of in-vivo tissue optical properties”, a paper that was accepted on 17 Jul 2014 for publication in Journal of Biomedical Optics.  The paper describes the combination of structured illumination with SWIR imaging, to achieve spatial frequency domain imaging at wavelengths longer than previously reported.  The work was in collaboration with MTI lab members Christian Crouzet (PhD student) and Dr. Choi; former Durkin lab member John Nguyen (now a PhD student at Vanderbilt University); NSF graduate research fellow Kyle Nadeau; current Durkin lab members Dr. Rolf Saager, Rebecca Rowland (undergraduate student researcher), and Dr. Durkin; Dr. Tromberg; and Dr. Frank Jaworski of Raytheon Vision Systems.  Congratulations all!  [pdf]

Farewell to Chelsea Pittman

We bid a fond farewell to Chelsea Pittman, who most recently was the surgery specialist in our lab.  Chelsea joined the lab in 2012 as an undergraduate student researcher who worked closely with Sean White (then a graduate student, now a postdoctoral scholar in the lab) on in-vivo microscopy focused on study of the body’s reaction to engineered tissue implants.  Chelsea is a co-author on one paper (White et al., Tissue Engineering Part A, http://www.ncbi.nlm.nih.gov/pubmed/24593148), and she provided critical to several ongoing projects currently funded by the National Institutes of Health and American Society for Laser Medicine and Surgery.  We are sad to see her leave, but we are excited for her as she moves on to continued education in the Nursing Studies program at Drexel University.  Good luck Chelsea!

Chelsea's going-away lunch at All That Barbeque in Irvine, CA.  Chelsea is fourth from the left.

Chelsea’s going-away lunch at All That Barbeque in Irvine, CA. Chelsea is fourth from the left.  Picture courtesy fo Ben Lertsakdadet.